Blocking nociceptor CGRP to RAMP1 signaling in macrophages reduces endometriosis pain and lesion growth in a mouse model of the disease.

Integrative multiomic analysis identifies three molecular subtypes of NAFLD associated with distinct clinical risks.

Emerging CAR-T technologies offer transformative potential to address the needs of patients with autoimmunity or other diseases beyond cancer.

Protumoral foamy macrophages are associated with poorer survival in humans with glioblastoma and can be targeted by lipid droplet inhibitors.

A fasting-mimicking diet treatment restores renal function in glomerulopathy and provides preliminary evidence of beneficial effects in chronic kidney disease.

Statistical modeling allows the classification of individual tumor responses and assessment of treatment effects with heterogeneous response.

A granulovacuolar degeneration–associated form of necroptosis represents an Alzheimer’s disease–related type of nerve cell death that can be inhibited.

A single-cell transcriptomic atlas with integrated proteomics for the prefrontal cortex of late-stage Parkinson’s disease human brains is presented.

Current COVID-19 vaccines induce suboptimal respiratory mucosal immunity even after mRNA boosters (Declercq et al. and Lasrado et al., this issue).

COVID-19 mRNA booster vaccines induce limited mucosal immunity.

mRNA booster vaccines for SARS-CoV-2 induce circulating virus neutralizing antibodies that may enter the respiratory mucosa.

Mutation load and clonal hematopoiesis are similar between donors and recipients, even decades after hematopoietic cell transplantation.

Stromal reprograming by FAK inhibition overcomes RAS-MAPK inhibition resistance and enhances responses to therapy in pancreas cancer models.

Potent lysyl-tRNA synthetase inhibitors advance our understanding of desirable properties for achieving efficacy in cryptosporidiosis animal models.

Human FOXP3 promoter–driven OX40L–CAR-Tregs potently suppress alloreactivity and control graft-versus-host disease.

Nuclide and optical probes targeting TROP2 support the identification of margins during breast-conserving surgery in patients with breast cancer.

Versatile PAMless CRISPR base editors enable efficient and precise therapeutic correction of CGD mutations in hematopoietic stem and progenitor cells.

MTNR1A loss-of-function variant rs374152717 impairs bone turnover and provides evidence of a genetic etiology of idiopathic osteoporosis.

After nerve injury, follistatin is up-regulated and interacts with IGF1R to activate Nav1.7 in nociceptive neurons, leading to neuropathic pain.

Increased airway NK cells, altered circulating NK cell immunophenotype, and cytotoxic dysfunction are associated with severe pediatric RSV infection.