Science
Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice | Science Translational Medicine
Intestinal helminth infection blunts T cell responses induced by SARS-CoV-2 vaccines in mice.
Categories: Science
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies | Science Translational Medicine
CNP-based agonist agent improves the perfusion of solid tumor tissues to reactivate immune response and increase efficacy of anticancer therapies.
Categories: Science
Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson’s disease | Science Translational Medicine
Microglia-specific IL-10 gene delivery protects from neurodegeneration in Parkinson’s disease mice by reshaping immune response and microglial state.
Categories: Science
Stress-induced eosinophil activation contributes to postoperative morbidity and mortality after lung resection | Science Translational Medicine
Lung resection results in eosinophil activation that damages the remaining pulmonary tissue in an iNOS-dependent manner.
Categories: Science
Astronomers might finally have explanation for mysterious Wow! signal
A radio signal detected in 1977, sometimes claimed as evidence for aliens, may have been caused by a laser-like beam of microwave radiation
Categories: Science
Can AI make crime scene investigations less biased?
AI tools could help eliminate human bias in forensic investigations, say UCL scientists, who are using eye-tracking technology to study decision-making in skeletal analysis and crime scene examinations
Categories: Science
AI could help shrinking pool of coders keep outdated programs working
Computer code dating back to the 1960s is still vital to banks, airlines and governments, but programmers familiar with the language are in short supply. Now AI models are being trained to fill the skills gap
Categories: Science
Lightning can make energy waves that travel shockingly far into space
Lightning strikes near Earth give rise to electromagnetic waves called “whistlers” that can carry energy high enough above our planet to pose a risk to satellites and astronauts
Categories: Science
Strange meteorites have been traced to their source craters on Mars
Mars rocks that were blasted off the surface of the Red Planet millions of years ago have been traced back to craters where they originated, which could transform our understanding of Mars’s volcanism and evolution
Categories: Science
Interstellar to Doctor Who: Sci-fi dramas getting science mostly right
Space exploration has long been a staple of sci-fi films and TV, yet most play fast and loose with the laws of physics, and scientific fact often couldn't be further from the truth
Categories: Science
Hellish conditions have warped an Earth-like planet into an egg
Planets that orbit close to their parent stars are blasted with radiation and contorted by gravity – and the exoplanet TOI-6255b might be the most extreme example yet
Categories: Science
Why the T in ChatGPT is AI's biggest breakthrough - and greatest risk
AI companies hope that feeding ever more data to their models will continue to boost performance, eventually leading to human-level intelligence. Behind this hope is the "transformer", a key breakthrough in AI, but what happens if it fails to deliver?
Categories: Science
Don't disrespect Alan Turing by reanimating him with AI
Plans to create an interactive AI model of the legendary code breaker Alan Turing are reckless and problematic, says Matthew Sparkes
Categories: Science
Erratum for the Research Article “A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation” by D. Gesty-Palmer et al. | Science Translational Medicine
Because of an error introduced when the figures were being assembled for the Research Article “A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation” by D. Gesty-Palmer et al. more than 16 years ago, the same image was inserted in Fig. 4A for vehicle-treated samples for WT and βarrestin2 KO only rotated 90°. This error does not alter any of the data or conclusions of the paper, including those shown in Fig. 4. The histomorphometry images in Fig. 4A were included for illustrative purposes only, and hence the images for vehicle-treated samples have been deleted in the revised figure. The actual data are shown in the bar graphs in the remaining panels of the figure.
Categories: Science
An identity crisis for lung cancer cells | Science Translational Medicine
Omic analysis of clinical specimens undergoing histological transformation defines targetable drivers to prevent plasticity and treatment resistance.
Categories: Science
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier | Science Translational Medicine
Systemic dosing with a transferrin receptor binding molecule delivering antisense oligonucleotides resulted in RNA target knockdown in the mammalian brain.
Categories: Science
Development and preclinical validation of 2-deoxy 2-[18F]fluorocellobiose as an Aspergillus-specific PET tracer | Science Translational Medicine
Radiolabeled [18F]fluorocellobiose is shown to be an Aspergillus-specific diagnostic PET tracer in mouse models of myositis and pneumonia.
Categories: Science
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model | Science Translational Medicine
Mechanical ventilation at minimal driving pressure optimizes local lung biomechanics in a ventilator-induced lung injury and endotoxemia ovine model.
Categories: Science
Acyl-CoA binding protein for the experimental treatment of anorexia | Science Translational Medicine
Stress- or chemotherapy-induced anorexia can be treated in mice by supplementation of the appetite-stimulatory hormone ACBP/DBI.
Categories: Science
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice | Science Translational Medicine
Natural killer cells promote the formation of neutrophil extracellular traps and suppress pathological angiogenesis in a mouse model of nvAMD.
Categories: Science