Reversible attention deficits after early adversity are mediated by sleep across species.

Multispecific antibodies to SARS-CoV-2 increase pseudovirus neutralization breadth and potency and inhibit immune escape in vitro.

Mitochondrial creatine kinase 2 is decreased in type 2 diabetes, which impairs skeletal muscle mitochondrial function.

Unraveling the cancer-stroma interactome in myelofibrosis reveals galectin-1 as an actionable target.

Temozolomide resistance in MGMT-methylated glioblastoma is mediated by a CHK1/DDX46 axis that can be blocked by the addition of a CHK1 inhibitor.

A microbiome-directed food targeting specific gut bacterial taxa promotes growth in Bangladeshi children recovering from severe acute malnutrition.

LRRK2 kinase activity drives reactive oxygen species production in Parkinson’s disease through regulation of NADPH oxidase 2.

A tumor-specific peptide translated from a MYC-associated uORF binds to tropomyosin receptor kinase B and promotes glioblastoma growth.

Glucocorticoid receptor activation in renal tubular epithelial cells amplifies DNA damage, impairs mitochondrial bioenergetics, and worsens injury.

Scientific and clinical advances have expanded our ability to understand, prevent, and treat diverse forms of skin fibrosis.

Inhibition of CYP1B1 in HSCs and trehalose/lactotrehalose dosing show preclinical antifibrotic effects in male animals.

Reducing excitatory neuron swelling improved locomotor functional recovery after spinal cord injury in mice.

Spermidine is essential for the function of leukemia stem and progenitor cells through the regulation of KAT7 expression.

Nerve injury promotes IgG secretion from B cells, activating Fc gamma receptors in the dorsal root ganglia and spinal cord, leading to pain in mice.

Neutrophil extracellular traps are present in the urinary tract, help prevent ascending infection, and underlie positive urine dipsticks.

An extrathymic AIRE expression system uncovered a deep intronic AIRE variant that causes APECED and can be targeted with antisense oligonucleotides.

Preschool-age children mount a different adaptive immune response to SARS-CoV-2 than adults.

Radiation dose heterogeneity promotes systemic antitumor immunity through induction of diverse immune activation pathways.

ARGX-119 is a first-in-class MuSK agonist monoclonal antibody in clinical development for treatment of neuromuscular diseases.

Ultrasound perfusion metrics are correlated with acute spinal cord injury severity in rats and humans.