Systemic dosing with a transferrin receptor binding molecule delivering antisense oligonucleotides resulted in RNA target knockdown in the mammalian brain.

Radiolabeled [18F]fluorocellobiose is shown to be an Aspergillus-specific diagnostic PET tracer in mouse models of myositis and pneumonia.

Mechanical ventilation at minimal driving pressure optimizes local lung biomechanics in a ventilator-induced lung injury and endotoxemia ovine model.

Stress- or chemotherapy-induced anorexia can be treated in mice by supplementation of the appetite-stimulatory hormone ACBP/DBI.

Natural killer cells promote the formation of neutrophil extracellular traps and suppress pathological angiogenesis in a mouse model of nvAMD.

An exosome-based photoinducible protein delivery system enables targeted epigenome editing to reduce Bace1 in mouse models of Alzheimer’s disease.

Pharmacological inhibition of BTK attenuates alcohol-induced granulopoiesis and neutrophil-mediated liver damage in a preclinical model of alcohol-associated hepatitis.

Piplartine modulates TRPV1/AKT activity and attenuates aminoglycoside-induced hearing loss in mice.

A self-amplifying RNA vaccine for enterovirus D68 elicits neutralizing antibodies in mice and nonhuman primates and protects mice from disease.

Guanidino lipoglycopeptides show potent in vitro activity and in vivo efficacy against clinically relevant Gram-positive pathogens.