Temozolomide resistance in MGMT-methylated glioblastoma is mediated by a CHK1/DDX46 axis that can be blocked by the addition of a CHK1 inhibitor.

A microbiome-directed food targeting specific gut bacterial taxa promotes growth in Bangladeshi children recovering from severe acute malnutrition.

LRRK2 kinase activity drives reactive oxygen species production in Parkinson’s disease through regulation of NADPH oxidase 2.

A tumor-specific peptide translated from a MYC-associated uORF binds to tropomyosin receptor kinase B and promotes glioblastoma growth.

Glucocorticoid receptor activation in renal tubular epithelial cells amplifies DNA damage, impairs mitochondrial bioenergetics, and worsens injury.

Hit. Der.

What is represented by the following?


Hit. Der.


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Cracks running through samples of asteroid Ryugu were probably formed by the repeated thawing and freezing of water inside it, which could have helped asteroids like this carry the building blocks of life to early Earth

Astronomers have detected an exoplanet around Barnard’s star, one of the sun’s closest neighbours, but it is too hot for liquid water or life

Google, Microsoft and others have taken big steps towards error-free devices, hinting that quantum computers that solve real problems aren’t far away

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out

A US standards agency has issued new guidance saying organisations shouldn’t require users to change their passwords periodically – advice that is backed up by decades of research

Try to determine the pattern in the first two sets of words below, in order to fill in the blank for the missing word in the third set.

1. ally, range, light, vent, rope
2. lake, round, raft, error, fact
3. wing, mount, right, motion, ____


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Should a mystery arrive, then to learn do I strive
Should you change my first, into anger do I burst

What are we?


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For each item below, construct the answer word which has been fragmented, by joining/adding together its "fragment" words which are the smaller words you must figure out from the clues provided.

The hint gives the respective number of letters in each "fragment" word, and the number of letters in each answer word (shown in brackets).

Example: rectangular block + advance/profit Hint: 3 letters + 4 letters (= 7 letters) Answer: bargain (bar + gain)


1) block + man of honour
2) writing instrument + canticle
3) forehead + express a melody
4) musical group + length of existence
5) males + high card
6) at that place + front


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Complete the sentences below so that they make sense, by filling in the blanks of each sentence with two words which are anagrams of each other.

For example, given the sentence:

"Rachel originally planned to buy an apple, but found a bargain and bought a _____ instead, because it was fresh and _____.",

the two words would be "peach" and "cheap" respectively.


1. The dog approached the fire hydrant and lifted its hind leg, but just before being able to initiate a _____, its _____ yanked its leash in order to keep moving forward.

2. After hearing the banging _____ for three hours, they pleaded with the protesters to _____.

3. The bus _____ brought along her umbrella due to the rain, but was hoping that _____ weather would be on the way soon.

4. As he noticed that dinner time was about to _____ up, he hastily prepared to fry a _____.


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For each of the following, find a word that may be placed in front of each of the three words in the group to form three new valid words. The resulting "binary" words may be singular (possibly hyphenated), or phrasal (i.e. the two component words are separated by a space) in construction.

For example, given: "light, rise, tide", you would need to find the word "high", which, when placed in front of these words, results in the three new valid words: "highlight", "high-rise", and "high tide" respectively.


1. line, post, tender
2. room, rack, tails
3. service, stick, sync
4. on, light, check


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My first is of a physical dimension
My second is to browse with transactional intention
My whole facilitates vehicular retention

What am I?


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For each of the following, find a word that may be placed in front of each of the three words in the group to form three new valid words. The resulting "binary" words may be singular (possibly hyphenated), or phrasal (i.e. the two component words are separated by a space) in construction.

For example, given: "light, rise, tide", you would need to find the word "high", which, when placed in front of these words, results in the three new valid words: "highlight", "high-rise", and "high tide" respectively.


1. eye, school, property
2. drive, point, flood
3. house, guard, area
4. found, bell, waiter


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I'm not some kind of villain or jerk
But I like to do your dirty work

Whenever numbered arrows apply
My brothers should assist you, not I

Despite attending you faithfully
Soon you will take everything from me

What am I?


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What number comes next in this sequence?

2088, 2092, 2096, ____


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